Fulvic Ionic Minerals (Fulvic Acid, Humic Acid, Essential Amino Acids & Trace Minerals),
Organic Freeze-Dried Cupuacu, Organic Freeze-Dried Acai, Organic Siberian Chaga Mushroom,
Japanese Red Pine Needle Oil & Organic Medicinal Herbs
ADDITIONAL INFO ON PINE OIL
Our Pine needle oil is extracted from the needles of very special Japanese Red Pine Trees. These trees are indigenous to very few regions of the world. Optimally Organic Japanese Red Pine Needle Oil is derived from pristine high mountains in Korea.
For thousands of years, Traditional Chinese Medicine and Traditional Korean Medicine have utilized this precious oil for treating very serious health issues. Their medical books list 170 health benefits of the Japanese Red Pine Needle Oil and include records of countless testimonials. It was most often used to cleanse the body of toxins and repair cellular damage. More recent studies over the past few decades give great merit to their claims.
PLEASE BE AWARE, NOT ALL PINE OIL IS FIT FOR HUMAN CONSUMPTION.
~THE ABILITY TO TAKE THIS OIL INTERNALLY MAKES IT VERY SPECIAL.~
AVAILABLE IN CAPSULES TOO!!!
As many harmful carcinogenic and mutagenic agents are produced which is causing environmental pollution. It is essential to find effective antimutagenic compounds with few side effects for the treatment of cancer and other disease.
This study was performed to investigate the biological activities-antimutangenic effect, anticancer effect, antibacterial effect of main pine needle extracts. Pine needle ethanol extracts by themselves did not show any mutagenicity with all over the concentrations of this experimental ranging 0~800 microgram/plate.
Inhibitory effects of ethnol extracts were observed on mutagenicity induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), 4-nitroquinoline-1-oxide(4NQO),3-amino-1,4-dimethyl1-5H-pyro-(4,3-b)indol(Trp-P-1) and Benzo(a)Pyrene Salmonella typhimurium reversion assay.
The ethanol extracts of pinus densiflora strongly inhibited the mutangenicity induced by MNNG on Salmonella typhimurium TA98 and TA100.
In addition we fractionated the ethanol extracts of pine needle with diethyether, chloroform, ethyl acetate, butanol and water. Among the solvent fractions of ethanol extracts from pine needle, the diethylether fractions(200 microgram/plate) of Pinus koraiensis significantly reduced the mutangenicity induced by TRP-P-1 in Salmonella typhimurium TA100 with S-9 mix.
The ethanol extracts of pine needles showed the strong antimocrobaial activities against bacteria. Among each extraction, Pinus koraiensis and Pinus densiflora had the strongest antibacterial activity against strain Listeria moncytogenes ARCC1911 and Bacillus cereus IFO 3514.
The anticancer effect of pine needle extracts against cancer cell lines, including Human Gastric carcinoma(KATOIII), Human lung carcinoma(A549), Human hepatocellular(Hep3B), Human Fibrosarcoma(HT1080) and Human Breast adenocarcinomal (MCF-7) was investigated.
The results showed that growth inhibition rates of the cancer cells in medium containing pine needle extracts were inhibited gradually to a significant degree in proportion to the increase of the extract concentration.
Especially, the ethenol extract of pinus koraiensis significantly reduced the growth of A549, Hep4B and MCF-7 cancer cells.
In vivo genotoxictic effect of pine needle extracts were evaluated by micronucleus test using ICR male mice. MNNG was used as standard clastogens. Each extracts by themselves did not induce an increased frequencies of micronucleated polychromatic erythrocytes (MNPCEs). There were significant decrease in the frequencies of MNPCEs when mice recieved the extracts of Pinus densiflora and Pinus koraiensis both 36h before(40 mg/kg) and 36h before MNNG(150 mg/kg) injection.
These results indicate that extracts of pine needles have a strong modulatory effects on mutagen-induced mutagenicity and MNPCEs.
Sample citations and references on this thesis.
1. Ames, BN: Dietary carcinogens and anticarcinogens(oxygen radicals and degenerative deseases), Science., 221,1256 (1983)
2. Angela, M., Martin, C: Comparison of 5 microplate colorimetric assays for in vitro cytotoxicity testing and cell proliferation assays. Cytotechnology., 11,49 (1993)
5. Doll, R. and Peto,R: The cause if cancer: Quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst., 66(1), 1191(1981)
6. Goldin, A., Scheparts. SA., Venditti, J.M. and Devita, V.T.: Historical development and current strategy of the National Cancer Institute drug development program. In Methods in Cancer Research, Vol.16. Cancer Drug Development, Part A., Devita V.T. and Busch H. (Ed.), Academic Press, New York, p.165 (1979)
7. Graham, S.: Towards a dietary prevention of cancer. Epidemiol. Rev., 5, 38
22. Liu, M., Zho, G.: Study on mutagenic and antimutagenic effects of 41 chinese medicinal herbs. Carcinogen. Mutagen. Teratogent., 4, 25-28 (1992)
29. Moon, S.H., Kim, J.O. Rhee, S.H. Park, K.Y., Kim, K.H. Rhew, T.H.: Antimutagenic effects and compounds identified from hexane fraction of permisimmon leaves. J. Korean Soc. Food Nutr., 22,334 (1993)
66. Yoon Hyung, Lee, Yong Soon, Choi and San Young, Lee: Study on the screening and application of 3-hydroxy-3-methylglutaryl CoA reductase inhibitor from Pinus strobos extracts. Collasteral reduction: . Korean Soc. Food Nutr., 25,188 (1996)
All information contained on this website is based on research and testing to date and is for informational and educational purposes and is not intended to make any unsupported medical claim or the claim that any product is intended to cure or prevent any disease. These statements have not been evaluated by the Food & Drug Administration (FDA). Any serious health concern should be treated by a qualified medical practitioner. Pregnant or nursing mothers should consult their physician prior to using any nutritional supplement. (complete product disclaimer page)